Mon, Aug 26 | Campus Limpertsberg

TCP Seminar: Ali HAKAMI ZANJANI

Thermodynamics and Aggregation Kinetics of Lysozyme-Derived Peptides
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Time & Location

Aug 26, 2019, 2:00 PM – 3:00 PM
Campus Limpertsberg, Limpertsberg, 1511 Luxembourg

About the Event

Many serious progressive diseases such as Alzheimer’s and Parkinson’s are related to undesirable amyloid aggregation. From a positive perspective, functional amyloids have applications as robust and versatile biomaterials in nature, nanotechnology, and biomedicine. In this work the thermodynamics and aggregation kinetics of the ILQINS hexapeptide, a biological material derived from hen’s egg-white lysozyme, are studied. Also solution X-ray scattering and X-ray crystallography of the IFQINS hexapeptide as the human homologue of ILQINS are compared to simulation, verifying that at least two metastable polymorphic structures exist for this system which are substantially different at the atomistic scale.

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The work of Prof. Alexandre Tkatchenko is supported in part by the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement n. 725291)  and by FNR.